Pure Fisetin
(Cotinus coggygria)
400mg Capsules
Fisetin: a Powerful senotherapeutic
Fisetin is a bioactive flavonol molecule found in fruits and vegetables, such as strawberry, apple, persimmon, grape, onion, and cucumber. Several studies have reported fisetin to have neurotrophic, anticarcinogenic, and anti-inflammatory benefits. [1] Fisetin's anti-aging benefits are thought to be the result of its ability to eliminate cells that have undergone a process called senescence. Senescence is when a cell ages and permanently stops dividing but does not die. Over time, large numbers of these cells build up in tissues throughout the body and can release harmful substances that cause inflammation and damage to nearby healthy cells.
Several clinical studies are currently underway, including testing whether fisetin can improve physical function in breast cancer survivors, and in another study, comparing fisetin to the D+Q senolytic treatment (Dasatinib and Quercetin) in reducing frailty of adult survivors of childhood cancer. In a study that measured age via an epigenetic clock, combining D+Q with fisetin suggested that fisetin provides additional benefits beyond just senolytic activity, such as improved cognitive function and neuroprotection, and might be beneficial in modulating the effects of D+Q. [2]
natural compounds that demonstrate Potent senolytic activity
A 2018 study [3] set out to test ten flavonoids for their senolytic properties. The study acknowledged that D+Q is a potent senolytic, improving numerous age-related conditions, including frailty, osteoporosis, and cardiovascular disease. However, this study aimed to identify natural flavonoids with even more potent senolytic activity.
The study examined critical connectivity tissue (human fibroblasts) that had become senescent from oxidative and genotoxic stress. They further tested the flavonoids on mice, evaluating age-related histopathology, disease markers, health span and lifespan. Of the 10 flavonoids tested, fisetin was the most potent senolytic. When they treated the old mice. Fisetin reduced senescent markers in multiple tissues, consistent with a hit-and-run senolytic treatment like D+Q. It was determined that Fisetin demonstrates senotherapeutic activity in both human and mice tissue. In mice, it was found that fisetin restored tissue homeostasis, reduced age-related pathology, and extended median and maximum lifespan.
the science behind fisetin
It has been demonstrated that fisetin supports senescence by activating and regulating AMPK, MAPK, and mTOR pathways while also inhibiting CDK1, and CDK4 kinase enzymes. [4] A 2015 study indicated that AMPK activation can delay aging [5], while a 2019 study demonstrated mTOR inhibition has profound effects on life span and age-associated phenotypes across a wide array of organisms. [6]
mTOR is a protein kinase that controls cellular metabolism, catabolism, immune response, autophagy, survival, proliferation, and migration, to maintain cellular homeostasis. It is the target of the smart drug Rapamycin, the only compound known to extend mammalian lifespan. We have recently discovered that certain natural compounds might also inhibit / regulate mTOR, such as fisetin.
formulating a natural d+q mimetic
Natural senolytic supplements are widely available, but notably, NEUROmergence, which contains fisetin, is formulated with seven additional compounds known to target the same pathways inhibited by Dasatinib. NEUROmergence also contains Quercetin to further align it to the Dasatinib + Quercetin treatment. It has been called a break-through discovery, and celebrated for both its effectiveness, and enhanced safety profile when compared to Dasatinib. Every ingredient found in NEUROmergence is available individually, in capsule and powder form.
ATTENTION:
If pregnant, nursing, or trying to conceive, do not use this product. If you take medications, have preexisting conditions, or suffer from allergies of any kind, please consult your physician before taking this, or any other dietary supplements. These statements have not been evaluated by the Food and Drug Administration.
These products are not intended to diagnose, treat, cure, or prevent any disease.
ABOUT MDS LABS
CITATIONS:
[1] Khan N, Syed DN, Ahmad N, Mukhtar H. Fisetin: a dietary antioxidant for health promotion. Antioxid Redox Signal. 2013 Jul 10;19(2):151-62. doi: 10.1089/ars.2012.4901. Epub 2012 Dec 18. PMID: 23121441; PMCID: PMC3689181.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3689181/
[2] Lee E, Carreras-Gallo N, Lopez L, Turner L, Lin A, Mendez TL, Went H, Tomusiak A, Verdin E, Corley M, Ndhlovu L, Smith R, Dwaraka VB. Exploring the effects of Dasatinib, Quercetin, and Fisetin on DNA methylation clocks: a longitudinal study on senolytic interventions. Aging (Albany NY). 2024 Feb 22; 16:3088-3106.
https://doi.org/10.18632/aging.205581
[3] Yousefzadeh MJ, Zhu Y, McGowan SJ, Angelini L, Fuhrmann-Stroissnigg H, Xu M, Ling YY, Melos KI, Pirtskhalava T, Inman CL, McGuckian C, Wade EA, Kato JI, Grassi D, Wentworth M, Burd CE, Arriaga EA, Ladiges WL, Tchkonia T, Kirkland JL, Robbins PD, Niedernhofer LJ. Fisetin is a senotherapeutic that extends health and lifespan. EBioMedicine. 2018 Oct;36:18-28. doi: 10.1016/j.ebiom.2018.09.015. Epub 2018 Sep 29. PMID: 30279143; PMCID: PMC6197652.
https://pubmed.ncbi.nlm.nih.gov/30279143/
[4] Baier A, Szyszka R. Compounds from Natural Sources as Protein Kinase Inhibitors. Biomolecules. 2020 Nov 12;10(11):1546. doi: 10.3390/biom10111546. PMID: 33198400; PMCID: PMC7698043.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7698043/
[5] Stancu AL. AMPK activation can delay aging. Discoveries (Craiova). 2015 Dec 31;3(4):e53. doi: 10.15190/d.2015.45. PMID: 32309575; PMCID: PMC6941559.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6941559/
[6] Papadopoli D, Boulay K, Kazak L, Pollak M, Mallette FA, Topisirovic I, Hulea L. mTOR as a central regulator of lifespan and aging. F1000Res. 2019 Jul 2;8:F1000 Faculty Rev-998. doi: 10.12688/f1000research.17196.1. PMID: 31316753; PMCID: PMC6611156.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6611156/
Pure Fisetin
(Cotinus coggygria)
400mg Capsules
- Includes 400mg per capsule of 99% Pure Fisetin Isolate from Cotinus coggygria Extract
- Promotes Healthy Aging
- Advanced Senolytic Support
- Natural, Gluten Free, Vegan, Non GMO
- Every batch HPLC tested for purity and tracked by lot #
- Includes 30 Capsules per bottle
- Free US Shipping
Fisetin: a Powerful senotherapeutic
Fisetin is a bioactive flavonol molecule found in fruits and vegetables, such as strawberry, apple, persimmon, grape, onion, and cucumber. Several studies have reported fisetin to have neurotrophic, anticarcinogenic, and anti-inflammatory benefits. [1] Fisetin’s anti-aging benefits are thought to be the result of its ability to eliminate cells that have undergone a process called senescence. Senescence is when a cell ages and permanently stops dividing but does not die. Over time, large numbers of these cells build up in tissues throughout the body and can release harmful substances that cause inflammation and damage to nearby healthy cells.
Several clinical studies are currently underway, including testing whether fisetin can improve physical function in breast cancer survivors, and in another study, comparing fisetin to the D+Q senolytic treatment (Dasatinib and Quercetin) in reducing frailty of adult survivors of childhood cancer. In a study that measured age via an epigenetic clock, combining D+Q with fisetin suggested that fisetin provides additional benefits beyond just senolytic activity, such as improved cognitive function and neuroprotection, and might be beneficial in modulating the effects of D+Q. [2]
natural compounds that demonstrate Potent senolytic activity
A 2018 study [3] set out to test ten flavonoids for their senolytic properties. The study acknowledged that D+Q is a potent senolytic, improving numerous age-related conditions, including frailty, osteoporosis, and cardiovascular disease. However, this study aimed to identify natural flavonoids with even more potent senolytic activity.
The study examined critical connectivity tissue (human fibroblasts) that had become senescent from oxidative and genotoxic stress. They further tested the flavonoids on mice, evaluating age-related histopathology, disease markers, health span and lifespan. Of the 10 flavonoids tested, fisetin was the most potent senolytic. When they treated the old mice. Fisetin reduced senescent markers in multiple tissues, consistent with a hit-and-run senolytic treatment like D+Q. It was determined that Fisetin demonstrates senotherapeutic activity in both human and mice tissue. In mice, it was found that fisetin restored tissue homeostasis, reduced age-related pathology, and extended median and maximum lifespan.
the science behind fisetin
It has been demonstrated that fisetin supports senescence by activating and regulating AMPK, MAPK, and mTOR pathways while also inhibiting CDK1, and CDK4 kinase enzymes. [4] A 2015 study indicated that AMPK activation can delay aging [5], while a 2019 study demonstrated mTOR inhibition has profound effects on life span and age-associated phenotypes across a wide array of organisms. [6]
mTOR is a protein kinase that controls cellular metabolism, catabolism, immune response, autophagy, survival, proliferation, and migration, to maintain cellular homeostasis. It is the target of the smart drug Rapamycin, the only compound known to extend mammalian lifespan. We have recently discovered that certain natural compounds might also inhibit / regulate mTOR, such as fisetin.
formulating a natural d+q mimetic
Natural senolytic supplements are widely available, but notably, NEUROmergence, which contains fisetin, is formulated with seven additional compounds known to target the same pathways inhibited by Dasatinib. NEUROmergence also contains Quercetin to further align it to the Dasatinib + Quercetin treatment. It has been called a break-through discovery, and celebrated for both its effectiveness, and enhanced safety profile when compared to Dasatinib. Every ingredient found in NEUROmergence is available individually, in capsule and powder form.
ATTENTION:
If pregnant, nursing, or trying to conceive, do not use this product. If you take medications, have preexisting conditions, or suffer from allergies of any kind, please consult your physician before taking this, or any other dietary supplements. These statements have not been evaluated by the Food and Drug Administration.
These products are not intended to diagnose, treat, cure, or prevent any disease.
ABOUT MDS LABS
CITATIONS:
[1] Khan N, Syed DN, Ahmad N, Mukhtar H. Fisetin: a dietary antioxidant for health promotion. Antioxid Redox Signal. 2013 Jul 10;19(2):151-62. doi: 10.1089/ars.2012.4901. Epub 2012 Dec 18. PMID: 23121441; PMCID: PMC3689181.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3689181/
[2] Lee E, Carreras-Gallo N, Lopez L, Turner L, Lin A, Mendez TL, Went H, Tomusiak A, Verdin E, Corley M, Ndhlovu L, Smith R, Dwaraka VB. Exploring the effects of Dasatinib, Quercetin, and Fisetin on DNA methylation clocks: a longitudinal study on senolytic interventions. Aging (Albany NY). 2024 Feb 22; 16:3088-3106.
https://doi.org/10.18632/aging.205581
[3] Yousefzadeh MJ, Zhu Y, McGowan SJ, Angelini L, Fuhrmann-Stroissnigg H, Xu M, Ling YY, Melos KI, Pirtskhalava T, Inman CL, McGuckian C, Wade EA, Kato JI, Grassi D, Wentworth M, Burd CE, Arriaga EA, Ladiges WL, Tchkonia T, Kirkland JL, Robbins PD, Niedernhofer LJ. Fisetin is a senotherapeutic that extends health and lifespan. EBioMedicine. 2018 Oct;36:18-28. doi: 10.1016/j.ebiom.2018.09.015. Epub 2018 Sep 29. PMID: 30279143; PMCID: PMC6197652.
https://pubmed.ncbi.nlm.nih.gov/30279143/
[4] Baier A, Szyszka R. Compounds from Natural Sources as Protein Kinase Inhibitors. Biomolecules. 2020 Nov 12;10(11):1546. doi: 10.3390/biom10111546. PMID: 33198400; PMCID: PMC7698043.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7698043/
[5] Stancu AL. AMPK activation can delay aging. Discoveries (Craiova). 2015 Dec 31;3(4):e53. doi: 10.15190/d.2015.45. PMID: 32309575; PMCID: PMC6941559.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6941559/
[6] Papadopoli D, Boulay K, Kazak L, Pollak M, Mallette FA, Topisirovic I, Hulea L. mTOR as a central regulator of lifespan and aging. F1000Res. 2019 Jul 2;8:F1000 Faculty Rev-998. doi: 10.12688/f1000research.17196.1. PMID: 31316753; PMCID: PMC6611156.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6611156/
Reece –
You have a lot of great information here.
Jeff –
I was taking the Bio-Fisetin from Life Extensions but didn’t notice anything. Then I tried the Renue Senolytique and really liked it, until I found Neuromergence which I feel is superior. Helped increase my energy, improved my sleep, and also gave me a noticeable boost in my sex drive. I also started on their fisetin. I take it in between neuromergence cycles, and it gives me more energy and focus.