Pure Spermidine 20mg Anti aging Capsules

Spermidine: Nature’s Anti-Aging Solution

Spermidine, a naturally occurring polyamine found in foods such as aged cheese, mushrooms, soy products, and whole grains, has emerged as a promising compound in anti-aging research. Studies suggest it has the potential to extend lifespan and improve health as organisms age, particularly through its role in autophagy. In one study, spermidine extended the lifespan of mice by up to 25%. [1]

More recently, research on IL-11 inhibitors also indicated a similar 25% lifespan increase in mice. [2] This discovery created excitement across social media. However, it's important to note that less than 5% of treatments effective in mice studies translate successfully to humans. While animal studies provide valuable data, casual readers can be misled without proper scrutiny. In reality, only human clinical trials can be evaluated to understand a compound's true potential. Spermidine has been well-studied, and we have a lot of information available to us in order to paint a clear picture of the potential benefits.

A Brief History of Spermidine

In 1676, Antonie van Leeuwenhoek, the father of microscopy, was the first person to observe bacteria. A year later, he noticed his own sperm under the microscope, and in the following year, he saw crystals forming in semen. [3] Centuries later, this compound was identified as spermine, a precursor to spermidine. Spermidine has since been recognized for its role in regulating cell growth and promoting autophagy, a key process for longevity.

The Role of Spermidine in Autophagy and Aging

Autophagy is the process by which cells break down and recycle their internal components. This essential process declines with age, leading to the accumulation of cellular waste, which can cause age-related diseases. Spermidine has been shown to enhance autophagy, potentially improving cellular function and longevity. [4] As we age, spermidine levels decline—by the time we reach our 50s, levels have decreased by about half. [5] Interestingly, certain non-aging mammals, such as naked mole rats, maintain high spermidine levels throughout their lives. This pattern has also been observed in human centenarians. [6]

Human Studies and Dietary Supplementation

Italian researchers found that by the time people reach their 70s, spermidine levels are about a third of what they were in middle age. However, people living into their 90s and beyond have been able to maintain youthful spermidine levels. It was found that declining levels can be replenished through a spermidine-rich diet or supplementation. However, most Spermidine supplements only contain wheat germ or wheat germ extract, and while this could work in theory, you would have to take the equivalent of ten grams of extract, or about twenty 500mg capsules to reach meaningful levels.

Pure spermidine, or Spermidine Trihydrochloride, was found to only partially restore spermidine levels, with the dose reaching maximum benefit around 15-20mg. However, another study showed that effective Spermidine levels are achievable through supplementation, but only when combined with certain polyphenols, particularly stilbenes like resveratrol and pterostilbene (found in blueberries). [7] Pterostilbene has demonstrated to be the most advantageous, due to its higher bioavailability, better membrane solubility, and stronger anti-inflammatory properties when compared to other stilbenes[8].

So to summarize, Spermidine supplementation with wheat germ extract is not practical. It shows a partial benefit when using pure spermidine, a meaningful benefit when combined with resveratrol, and the best results when combined with pterostilbene.

Spermidine Benefits Cognitive and Cardiovascular Health

Spermidine also shows promise for cognitive health. In one study, participants with mild dementia were given rolls enriched with wheat germ (versus wheat bran). The wheat germ group exhibited cognitive improvements that exceeded the results of all available anti-dementia treatments. [9]

Research also indicates that spermidine may support cardiovascular health. Studies show that regular intake of spermidine is linked to reduced blood pressure and a lower incidence of cardiovascular disease, likely due to its role in promoting healthy blood vessel function and improving metabolic parameters. [10]

NEUROmergence®: A Cutting-Edge Senolytic Supplement

NEUROmergence® by MDS Labs® is a phytochemical supplement designed to support longevity. It contains ingredients known to inhibit the same cellular pathways as the powerful D+Q senolytic treatment (a combination of Dasatinib and Quercetin). D+Q has demonstrated the ability to slow dementia, reduce Long-COVID-19 neuropathy, and improve skin elasticity.

NEUROmergence includes pure Spermidine Trihydrochloride and Pterostilbene. Spermidine was incorporated into the formulation due to its ability to inhibit SRC family kinases (SRC, FYN, and LYN), as well as BCL-2 enzymes, key pathways also targeted by Dasatinib. NEUROmergence is the only senolytic supplement to undergo Western blot assay, which was used to optimize its formula for maximum tyrosine kinase inhibition.

ATTENTION:

If pregnant, nursing, or trying to conceive, do not use this product. If you take medications, have preexisting conditions, or suffer from allergies of any kind, please consult your physician before taking this, or any other dietary supplements. These statements have not been evaluated by the Food and Drug Administration.

These products are not intended to diagnose, treat, cure, or prevent any disease.

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CITATIONS:

[1] Yue F, Li W, Zou J, Jiang X, Xu G, Huang H, Liu L. Spermidine Prolongs Lifespan and Prevents Liver Fibrosis and Hepatocellular Carcinoma by Activating MAP1S-Mediated Autophagy. Cancer Res. 2017 Jun 1;77(11):2938-2951. doi: 10.1158/0008-5472.CAN-16-3462. Epub 2017 Apr 6. PMID: 28386016; PMCID: PMC5489339.
https://pmc.ncbi.nlm.nih.gov/articles/PMC5489339/

[2] Widjaja AA, Lim WW, Viswanathan S, Chothani S, Corden B, Dasan CM, Goh JWT, Lim R, Singh BK, Tan J, Pua CJ, Lim SY, Adami E, Schafer S, George BL, Sweeney M, Xie C, Tripathi M, Sims NA, Hübner N, Petretto E, Withers DJ, Ho L, Gil J, Carling D, Cook SA. Inhibition of IL-11 signalling extends mammalian healthspan and lifespan. Nature. 2024 Aug;632(8023):157-165. doi: 10.1038/s41586-024-07701-9. Epub 2024 Jul 17. PMID: 39020175; PMCID: PMC11291288.
https://pmc.ncbi.nlm.nih.gov/articles/PMC11291288/

[3] Bachrach U. The early history of polyamine research. Plant Physiol Biochem. 2010 Jul;48(7):490-5. doi: 10.1016/j.plaphy.2010.02.003. Epub 2010 Feb 17. PMID: 20219382.
https://pubmed.ncbi.nlm.nih.gov/20219382/

[4] Eisenberg T, Knauer H, Schauer A, Büttner S, Ruckenstuhl C, Carmona-Gutierrez D, Ring J, Schroeder S, Magnes C, Antonacci L, Fussi H, Deszcz L, Hartl R, Schraml E, Criollo A, Megalou E, Weiskopf D, Laun P, Heeren G, Breitenbach M, Grubeck-Loebenstein B, Herker E, Fahrenkrog B, Fröhlich KU, Sinner F, Tavernarakis N, Minois N, Kroemer G, Madeo F. Induction of autophagy by spermidine promotes longevity. Nat Cell Biol. 2009 Nov;11(11):1305-14. doi: 10.1038/ncb1975. Epub 2009 Oct 4. PMID: 19801973.
https://pubmed.ncbi.nlm.nih.gov/19801973/

[5] Rudman D, Kutner MH, Chawla RK, Goldsmith MA, Blackston RD, Bain R. Serum and urine polyamines in normal and in short children. J Clin Invest. 1979 Dec;64(6):1661-8. doi: 10.1172/JCI109628. PMID: 500832; PMCID: PMC371320.
https://pubmed.ncbi.nlm.nih.gov/500832/

[6] Viltard M, Durand S, Pérez-Lanzón M, Aprahamian F, Lefevre D, Leroy C, Madeo F, Kroemer G, Friedlander G. The metabolomic signature of extreme longevity: naked mole rats versus mice. Aging (Albany NY). 2019 Jul 24;11(14):4783-4800. doi: 10.18632/aging.102116. PMID: 31346149; PMCID: PMC6682510.
https://pubmed.ncbi.nlm.nih.gov/31346149/

[7] Morselli E, Mariño G, Bennetzen MV, Eisenberg T, Megalou E, Schroeder S, Cabrera S, Bénit P, Rustin P, Criollo A, Kepp O, Galluzzi L, Shen S, Malik SA, Maiuri MC, Horio Y, López-Otín C, Andersen JS, Tavernarakis N, Madeo F, Kroemer G. Spermidine and resveratrol induce autophagy by distinct pathways converging on the acetylproteome. J Cell Biol. 2011 Feb 21;192(4):615-29. doi: 10.1083/jcb.201008167. PMID: 21339330; PMCID: PMC3044119.
https://pubmed.ncbi.nlm.nih.gov/21339330/

[8] Liu Y, You Y, Lu J, Chen X, Yang Z. Recent Advances in Synthesis, Bioactivity, and Pharmacokinetics of Pterostilbene, an Important Analog of Resveratrol. Molecules. 2020 Nov 6;25(21):5166. doi: 10.3390/molecules25215166. PMID: 33171952; PMCID: PMC7664215.
https://pubmed.ncbi.nlm.nih.gov/33171952/

[9] Pekar T, Bruckner K, Pauschenwein-Frantsich S, Gschaider A, Oppliger M, Willesberger J, Ungersbäck P, Wendzel A, Kremer A, Flak W, Wantke F, Jarisch R. The positive effect of spermidine in older adults suffering from dementia : First results of a 3-month trial. Wien Klin Wochenschr. 2021 May;133(9-10):484-491. doi: 10.1007/s00508-020-01758-y. Epub 2020 Nov 19. PMID: 33211152; PMCID: PMC8116233.
https://pubmed.ncbi.nlm.nih.gov/33211152/

[10] de Cabo R, Navas P. Spermidine to the rescue for an aging heart. Nat Med. 2016 Dec 6;22(12):1389-1390. doi: 10.1038/nm.4243. PMID: 27923032; PMCID: PMC5853099.
https://pubmed.ncbi.nlm.nih.gov/27923032/